Hereditary Antithrombin Deficiency Video Perspectives

Dana Angelini, MD, assistant professor at the Cleveland Clinic Lerner College of Medicine/Case Western Reserve University and associate staff at the Cleveland Clinic, spoke with Healio about the treatment and management of hereditary antithrombin deficiency.

In this video, Angelini discusses:

• What antithrombin deficiency is and its mechanism of action, as well as the rarity of hereditary antithrombin deficiency;
• The role of genetic makeup in hereditary antithrombin deficiency;
• How antithrombin deficiency is typically diagnosed, including a list of reasons for acquired antithrombin deficiency that must be first ruled out;
• Genetic testing and how it is beneficial for further classification but not typically used for diagnosis;
• The relative risk for unprovoked venous thromboembolism, or VTE, among patients with antithrombin deficiency, as well as the relative risk for recurrent VTE; and
• Patient subgroups with higher risk for blood clots, such as those who are pregnant.