Targeted Therapies in Multiple Myeloma Video Perspectives

Ajai Chari, MD

Chari reports research support from/being principal investigator for Janssen; and consulting/serving on scientific advisory board for AbbVie, Adaptive, Amgen, Antengene, BMS, Forus, Genentech/Roche, GSK, Janssen, Karyopharm, Millenium/Takeda and Sanofi/Genzyme.

July 18, 2024
2 min watch
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VIDEO: 'Paradigm shifting time in myeloma' as patients go from hospice-bound to remission

Transcript

Editor's note: This is an automatically generated transcript. Please notify editor@healio.com if there are concerns regarding accuracy of the transcription.

I will start with my experience in moving from New York to San Francisco. I've been in New York for 18 years and I had the privilege of caring for patients over many of those years. And when I was saying goodbye, I was reflecting on many of these patients that we had had hospice conversations. Because if you had exhausted all available therapies, that was something we had to talk about. And now, some of those very patients are in their most deep and durable remissions that they've ever been in years.

So talk about a paradigm shifting time in myeloma, you're taking hospice-bound patients and giving them complete remissions. I can't paint any clearer picture why this is so dramatic. And so if you gave numbers 60 to 100% response rate is a new placement of 20 to 30%, remissions lasting one to three years has now replaced three to four months. So it's incredible for patients I think that that's what's happening. And those are in patients who are heavily treated. Of course there's a great interest in moving these to earlier lines of therapy, 'cause we have to recognize that when we talk about outcomes in five to six lines of therapy, there's a lot of attrition. The people who are really high risk, rapidly growing, they don't get to five lines of therapy. And so we need to be moving these products earlier so that high risk patients can benefit earlier and earlier, not have to wait til they've exhausted everything. So it's a remarkable time in myeloma.