VIDEO: Developments in genetic sequencing for sarcomas
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Candace Haddox, MD, explored advances in genetic sequencing for sarcomas, which was a major theme of the Connective Tissue Oncology Society Annual Meeting, in this video interview with Healio.
“We’re making progress on two key fronts: the first is gaining a better understanding of heterogeneity not only across sarcoma subtypes, but even within subtypes and within single patients; and second, we’re leveraging these technologies to enhance clinical information on disease status and prognosis,” Haddox, a sarcoma medical oncologist at Dana-Farber Cancer Institute, said.
For example, in a presentation on osteosarcoma, researchers used whole genome sequencing on multiple regions from each patients’ tumor and found that “genomic alterations can differ significantly across regions within the same tumor,” according to Haddox.
Haddox also discussed a study warranting further investigation that looked at the genomic landscape of resistance mechanisms in gastrointestinal stromal tumor (GIST).
She also talked about an “interesting” presentation that demonstrated circulating tumor DNA burden was prognostic in patients with metastatic Ewing sarcoma.
References:
- Bauer S, et al. Paper 72. Presented at: Connective Tissue Oncology Society Annual Meeting; Nov. 1-4, 2023; Dublin.
- Cortes-Ciriano I, et al. Paper 7. Presented at: Connective Tissue Oncology Society Annual Meeting; Nov. 1-4, 2023; Dublin.
- Shulman DS, et al. Paper 65. Presented at: Connective Tissue Oncology Society Annual Meeting; Nov. 1-4, 2023; Dublin.
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