Osteosarcoma

CHICAGO — Time between therapy regimens can safely be offered to certain children with cancer to promote quality of life and explore goals of care without negatively affecting survival, according to data presented at ASCO Annual Meeting.

Individuals with tooth agenesis may be more likely to develop several different cancer types from childhood through young adulthood, according to results published in JAMA Network Open.

Candace Haddox, MD, explored advances in genetic sequencing for sarcomas, which was a major theme of the Connective Tissue Oncology Society Annual Meeting, in this video interview with Healio.

A 3-month-old girl is diagnosed with severe thrush resistant to treatment, along with persistent cutaneous rash, thought to be flaring episodes of candidiasis that never quite clear. What's your diagnosis?

Results showed compromised soft tissue status and Enterococcus spp. infection was associated with increased risk of recurrent infection in endoprosthetic replacement for patients with primary bone sarcomas or metastatic bone disease.

TAMPA, Fla. — In a video at the Orthopaedic Research Society Annual Meeting, Emily E. Seiden, BS, discusses romidepsin, which showed promise as a therapeutic to target micrometastases progression in osteosarcoma.

Venous tumor thrombus is a negative prognostic factor associated with several factors and most commonly occurs in patients with pelvic osteosarcoma, according to published results.

Innova Therapeutics Inc. has been granted rare pediatric disease designation by the FDA for its IVT-8086 osteosarcoma treatment.

A 3-year-old male living in Puerto Rico presented with progressive bilateral foot and lower extremity pain. He had been healthy until 4 months earlier, when he was diagnosed with influenza B. In addition to the common symptoms of influenza at that time, he also had the onset of pain in both feet. This pain continued, with a pattern of getting worse in the mornings, and reached a point where the patient refused to wear shoes. An orthopedic consultant failed to find a problem, and the patient was treated with pain medication, which had minimal effect. As his pain continued, he began having painful gingival swelling and erythema. His dentist referred him to a local hospital, where he was diagnosed with gingivitis and myositis, supported by an elevated CPK of 1760 and an ESR of 40, with a negative bone scan. The patient’s gingival edema worsened, with friable bleeding gums and ongoing leg pains, and he was taken to the regional medical center. Additional history revealed that he never had fever, night sweats or joint inflammation or swelling, but he did have a mild, transient rash, now resolved.