Bone/Mineral Metabolism News

Women aged at least 65 years with osteopenia were shown to be less at risk for fragility fracture when treated with zoledronate vs. placebo, according to study results reported at the American Society for Bone and Mineral Research Annual Meeting and published simultaneously in The New England Journal of Medicine.

Children with overweight and obesity assigned to receive vitamin D supplementation for 1 year experienced decreases in BMI and fat mass and a rise in HDL cholesterol vs. similar children assigned to placebo, according to study findings presented at the European Society for Paediatric Endocrinology annual meeting.

Adults with obesity who underwent Roux-en-Y gastric bypass experienced high-turnover bone loss and bone microarchitectural deterioration that persisted 5 years after the procedure, according to findings published in The Journal of Clinical Endocrinology & Metabolism.

Adolescents and young adults with vitamin D deficiency are nearly 2.5 times more likely to have metabolic syndrome vs. those without vitamin D deficiency, according to findings from an ongoing study of participants in China.

The use of medications associated with the development of osteoporosis has steadily increased across Denmark in the past 16 years, particularly by those most at risk for fracture, such as postmenopausal women and older adults, according to findings from a registry study published in Bone.

The upper-limit intake for vitamin D recommended by the Endocrine Society, when coadministered with calcium intake at the upper recommended level, is associated with increased odds for hypercalciuria when compared against recommendations from the Institute of Medicine, according to findings from a randomized, double-blind controlled trial.

Among white men, serum estradiol exerts a “robust causal effect” on fracture risk, independent of age, BMI, smoking status and physical activity level, according to findings from a large Mendelian randomization analysis.

Bone mineral density is an important potentially modifiable genetic predictor of osteoporotic fracture, whereas genetically influenced levels of vitamin D and calcium may not be, according to findings from a genome-wide association and Mendelian randomization study.

Osteoporosis is associated with a 1.3-fold increase in the risk for dementia among men, and a 1.2-fold increase among women, according to findings published in the Journal of Alzheimer’s Disease.

In adults with slightly elevated parathyroid hormone following Roux-en-Y gastric bypass surgery, supplementation with either calcium carbonate or calcium citrate did not restore normal PTH level, according to findings published in Clinical Endocrinology.