Magnesium supplementation does not improve androgen levels, hirsutism, sleep in PCOS
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Magnesium supplementation for 10 weeks led to no beneficial effects for women with polycystic ovary syndrome experiencing hyperandrogenism, hirsutism and impaired sleep quality, researchers reported in Health Science Reports.
“There is a lack of enough evidence regarding magnesium supplementation in women with PCOS,” Mahsa Gholizadeh-Moghaddam, MD, from the department of community nutrition at the Nutrition and Food Security Research Center at Isfahan University of Medical Sciences, Iran, and colleagues wrote. “Indeed, previous studies have not focused on the effect of magnesium supplementation on sleep quality and hyperandrogenism in these patients, and although some studies examined the impact of magnesium supplementation on hirsutism, such studies used magnesium in combination with other nutrients and did not evaluate the effect of magnesium alone on hirsutism in PCOS.”
This parallel randomized clinical trial included 64 women with PCOS who were randomly assigned to magnesium supplementation (n = 32; mean age, 31.7 years) or placebo (n = 32; mean age, 32.4 years) for 10 weeks. Those who received magnesium supplementation had one 250 mg tablet per day. Researchers measured hyperandrogenism, hirsutism and sleep quality at baseline and at 10 weeks.
Researchers observed no significant effect on hyperandrogenism (P = .51), hirsutism (P = .23) or sleep quality (P = .85) among women who received magnesium supplementation compared with women who received placebo. These findings remained unchanged following adjustment of baseline values of each factor and serum magnesium.
According to the researchers, some possible explanations for these nonsignificant findings are that most studies reporting a significant effect of magnesium supplementation used supplementation of magnesium plus other nutrients, and women in this study were not magnesium deficient and were given only 250 mg of magnesium when a higher dose may result in beneficial short-term effects.
“Consumption of dietary supplements has been increasing globally; however, several supplements have no beneficial effect on health and might have long-term negative side effects,” the researchers wrote. “Therefore, it would be advantageous for studies to evaluate the efficacy of dietary supplements in different diseases, such as PCOS.”
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