PREDICT3c study highlights risk factors for diabetes development in chronic pancreatitis
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Risk factors for type 2 diabetes and factors related to pancreatic disease were independent risk factors for diabetes development among adults with chronic pancreatitis, according to a cross-sectional study published in Diabetes Care.
“Because diabetes is such an important comorbidity in people with chronic pancreatitis, we need to be able to predict who with chronic pancreatitis might develop diabetes in the future,” Mark O. Goodarzi, MD, PhD, the Eris M. Field chair in diabetes research and director of the division of endocrinology, diabetes and metabolism at Cedars-Sinai Medical Center, told Healio. “We can use predictive models such as the one studied here to implement preventive measures.”
The cross-sectional study included 645 adults aged 18 to 75 years with chronic pancreatitis who were enrolled in the PROCEED study, an ongoing multicenter, longitudinal cohort study of chronic pancreatitis in the U.S., from June 2017 to August 2021. At enrollment, 276 participants had diabetes. Researchers assessed disease-related factors that may be associated with diabetes prevalence, including tobacco use, intensity of cigarette smoking, alcohol use and intensity of alcohol consumption. For pancreatic-related factors, researchers evaluated history of acute pancreatitis, age at first pancreatitis diagnosis, etiology based on physician assessment and history of endoscopic therapy or pancreatic surgery.
Results demonstrated that independent relationships of diabetes in chronic pancreatitis included type 2 diabetes risk factors, such as older age, overweight/obesity status, male sex, “non-white” race and tobacco use. In addition, pancreatic disease-related factors, such as history of acute pancreatitis complications, nonalcoholic etiology of chronic pancreatitis, exocrine pancreatic dysfunction, pancreatic calcification and pancreatic atrophy, were also correlated with diabetes development in chronic pancreatitis.
Researchers noted that risk factors for type 2 diabetes were predominant for diabetes that occurred before chronic pancreatitis, and pancreatic disease-related factors were predominant for diabetes that occurred after chronic pancreatitis.
“This study modeled diabetes risk factors in a cohort of individuals with chronic pancreatitis, of whom 43% had prevalent diabetes,” Goodarzi said. “Future work is needed to assess the ability of the model to predict incident cases of diabetes developing over time.”
For more information:
Mark O. Goodarzi, MD, PhD, can be reached at mark.goodarzi@cshs.org.
Reference:
- Study: Which People with Chronic Pancreatitis Will Develop Diabetes? https://www.cedars-sinai.org/newsroom/study-which-people-with-chronic-pancreatitis-will-develop-diabetes. Published Nov. 16, 2022. Accessed Nov. 16, 2022.
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