Genetics/Genomics News

Researchers in France observed that maternal inheritance of familial hypercholesterolemia was associated with greater odds of having subclinical coronary atherosclerosis compared with paternal inheritance of the gene mutation.

Biobank data suggest targeted polygenic risk score testing in younger adults with borderline or intermediate clinical risk may be a useful strategy for determining who will benefit most from initiating statin therapy, researchers reported.

The American College of Cardiology announced the late-breaking science lineup for its Scientific Session to be held March 4-6, 2023 in New Orleans and online.

A 6-month intervention with an exercise target of 10,000 steps per day may slow aortic root dilation in pediatric patients with Marfan syndrome, according to study data published in the Journal of the American Heart Association.

Spaceflight may place astronauts at increased risk for developing mutations that can lead to cancer and heart disease, according to a study published in Nature Communications Biology.

CVD risk increases with the severity of nonalcoholic fatty liver disease, and both CV and liver events are “highly related” to the degree of hepatic fibrosis present, according to a speaker.

Lipoprotein(a) levels of 67 mg/dL or more may be indicative of similar risk for premature MI as LDL of 180 mg/dL or more in patients with familial hypercholesterolemia, researchers reported.

CHICAGO — A novel CRISPR-based in vivo gene editing therapy reduced transthyretin levels in patients with hereditary transthyretin amyloidosis with cardiomyopathy, researchers reported at the American Heart Association Scientific Sessions.

Cardiomyopathy and HF diagnosis were more common among individuals with certain pathogenic variants compared with those without; however, prevalence was low, between 1% and 3% overall, researchers reported.

Individuals who acquired COVID-19 infection not requiring hospitalization had greatly increased risk for incident venous thromboembolism, according to results of an English population-based cohort study.