Genetics/Genomics News

Assessing odds for subclinical ASCVD by midlife based on maternal inheritance of FH.

NEW ORLEANS — Black female carriers of the V122I genetic variant for cardiac amyloidosis have substantially higher CVD and all-cause mortality risk, which grows with age, compared with noncarriers, researchers reported.

Haptoglobin gene expression in the blood appeared associated with anthracycline-related cardiomyopathy among childhood cancer survivors, according to study results.

NEW ORLEANS — Causal artificial intelligence used to augment a polygenic risk score for CAD helped estimate how much individual patients must lower their LDL, systolic BP or both to overcome inherited risk for a major coronary event.

Researchers in China have identified specific gut microbiome bacteria that may influence risk for several subtypes of ischemic stroke, according to research published in the European Journal of Preventive Cardiology.

Emerging precision medicine therapies targeting the molecular causes of cardiomyopathy and HF may improve the outlook for pediatric patients with HF, according to a review published in Translational Pediatrics.

A healthy lifestyle was associated with reduced risk for CVD among adults with familial hypercholesterolemia regardless of their familial hypercholesterolemia mutation status, researchers reported.

Cardiometabolic multimorbidity and midlife onset of cardiometabolic disease are significantly associated with an increased risk for dementia, and genetic background may underlie this association, researchers reported.

Researchers in France observed that maternal inheritance of familial hypercholesterolemia was associated with greater odds of having subclinical coronary atherosclerosis compared with paternal inheritance of the gene mutation.

Biobank data suggest targeted polygenic risk score testing in younger adults with borderline or intermediate clinical risk may be a useful strategy for determining who will benefit most from initiating statin therapy, researchers reported.