Genetics/Genomics News

Researchers have developed the first prediction model for the prediction of HF- and arrhythmia-related major adverse cardiac events in patients with mitochondrial diseases.

Approximately one in five adults with spontaneous coronary artery dissection with high-risk features had an increased burden of rare genetic variants on whole-exome sequencing, suggesting testing may be considered, researchers reported.

Angiotensin receptor blockers and beta-blockers slow down the expansion of the aorta in patients with Marfan syndrome and no previous aortic surgery, according to data reported at the European Society of Cardiology Congress.

A validated genome-wide polygenic risk score predicted clinically meaningful absolute risk for sudden arrhythmic death in a cohort of patients with CAD without severe left ventricular dysfunction, researchers reported.

A combined monogenic and polygenic risk assessment for CAD can identify individuals at high inherited risk before overt manifestation of traditional risk factors, potentially improving clinician decision-making on preventive interventions.

Data from a genetics-based study show PCSK9 inhibition does not affect cognition function or dementia risk; however, statin use may be associated with some impaired cognitive performance that is outweighed by any CV benefits.

Maintaining optimal CV health by following the American Heart Association’s Life’s Simple 7 protected people from stroke, even among those at high genetic risk, data from a long-term analysis show.

Researchers using RNA sequencing have identified unique cell and immune system signatures in tissue samples of children with congenital heart disease, offering a rare opportunity to better understand the origins of a complex disease.

Cardiologists should work with experienced centers performing genetic testing to identify and manage inherited cardiac conditions in young athletes and inform patients of risks and benefits, according to a new joint scientific statement.

Genetic inhibition of HMG-CoA reductase, a state that mimics long-term statin use, was associated with greater risk for developing cataract compared with individuals without genetic inhibition, researchers reported.