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Next-Generation Sequencing

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October 15, 2021
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Next-generation sequencing improves OS in ovarian cancer

New data have linked next-generation sequencing with improved overall survival in ovarian cancer, according to a presenter at the virtual ASCO Annual Meeting.

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July 23, 2021
5 min read
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Should there be universal molecular testing for all patients with gastrointestinal cancer?

In February, ASCO named molecular profiling driving progress in gastrointestinal cancers as its “Advance of the Year.” According to the American Cancer Society, taken collectively, gastrointestinal cancers have the highest incidence in the U.S. and, after lung cancer, are the second leading cause of cancer-related death. Identifying smaller subsets of patients based on tumor-specific and tumor-agnostic alterations provides insight as to who will benefit from personalized therapies. These subsets ultimately end up being substantial in size and, thus, universal testing should indeed be standard of care for all patients with metastatic gastrointestinal cancer.

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July 23, 2021
13 min read
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Molecular tumor testing transformative, yet 'under-optimized'

In 2010, results of the phase 2 BATTLE study demonstrated that choice of cancer therapy could be individualized based upon a patient’s tumor characteristics.

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June 05, 2021
4 min read
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Data reflect disparities in use of next-generation sequencing for lung cancer

Data reflect disparities in use of next-generation sequencing for lung cancer

Only one in four Black patients with advanced or metastatic non-small cell lung cancer underwent next-generation sequencing before first-line therapy compared with one in three white patients, according to results of a retrospective study.

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April 12, 2021
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Next-generation sequencing may detect gene variants linked to psychosis metabolism error

Next-generation sequencing may detect gene variants linked to psychosis metabolism error

Next-generation sequencing may help identify gene variants linked to inborn errors of metabolism among a subgroup of patients with psychosis, according to study results published in Journal of Psychiatric Research.

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December 17, 2020
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Serum markers, next-generation sequencing may diagnose infection in orthopedic surgery

Serum markers, next-generation sequencing may diagnose infection in orthopedic surgery

As difficulties exist in the diagnosis of infection in orthopedic surgery, researchers have turned their attention to serum markers, next-generation sequencing and phage therapy as possible diagnosis solutions, according to a presenter.

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August 27, 2020
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FDA approves Foundation Medicine pan-tumor liquid biopsy test

FDA approves Foundation Medicine pan-tumor liquid biopsy test

The FDA approved FoundationOne Liquid CDx, a comprehensive pan-tumor liquid biopsy test.

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August 07, 2020
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FDA approves Guardant360 CDx to identify EGFR mutations in non-small cell lung cancer

FDA approves Guardant360 CDx to identify <i>EGFR</i> mutations in non-small cell lung cancer

The FDA today approved Guardant360 CDx, a liquid biopsy companion diagnostic that uses next-generation sequencing, to identify EGFR mutations in patients with metastatic non-small cell lung cancer.

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