Cholesterol

Chronic hepatitis B virus infection was positively linked with severe hepatic necroinflammation in children with metabolic dysfunction-associated steatotic liver disease but did not appear to affect hepatic fibrosis, according to data.

Elevated lipid levels were associated with worsening structural and functional cardiac damage in adolescents and young adults, though in the case of LDL, the relationship was partially mediated by elevated BP and fat mass, data show.

In a cohort of older adults, those with the highest percentage of high-density lipoprotein cholesterol had a 27% higher risk of incident dementia, with the risk higher for those aged 75 years and older, according to a study.

Researchers reported that exposure to elevated LDL and elevated systolic BP before age 55 years is associated with increased coronary heart disease risk independent of later-life BP and cholesterol levels.

Adolescents and young adults who partake in more light physical activity have lower cholesterol levels, according to a study published in The Journal of Clinical Endocrinology & Metabolism.

Despite population-wide improvements in use of lipid-lowering medication and cholesterol control since 1999, significant racial and ethnic disparities persist among patients with a history of atherosclerotic CVD, researchers reported.

Statin use after breast cancer diagnosis was associated with reduced breast cancer mortality and reduced serum cholesterol levels compared with not using a statin, according to cohort study results published in JAMA Network Open.

PHILADELPHIA — In the CLEAR Outcomes cohort of patients with statin intolerance, inflammation predicted risk for CV events and death more strongly than cholesterol, researchers reported at the American Heart Association Scientific Sessions.

Data from a real-world cohort in Italy show female sex is the only independent variable associated with lower probability of achieving LDL target level for every risk category, regardless of whether the patient is prescribed statin therapy.

After pooling individual-level data from 112 cohort studies, researchers determined that more than 50% of cases of CVD can be attributed to five modifiable risk factors — BMI, systolic BP, non-HDL, current smoking and diabetes.