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Cholesterol

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July 13, 2023
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Elevated HDL, total cholesterol increase heart failure after menopause

Elevated HDL, total cholesterol increase heart failure after menopause

Postmenopausal women with high total or HDL cholesterol have an increased risk for heart failure compared with women with normal cholesterol levels, according to a study published in Menopause.

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July 11, 2023
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Cholesterol varies widely by country and region, showing need for targeted recommendations

Cholesterol varies widely by country and region, showing need for targeted recommendations

An analysis of nearly 500 million cholesterol readings globally shows LDL levels vary widely by country and region even after adjusting for age and sex, suggesting population-specific interventions may be needed, researchers reported.

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PCSK9 Inhibitors Topic Review

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein that binds to the LDL receptor on hepatocytes, promoting its internalization and degradation within the cell. [Repatha package insert;9a]

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June 13, 2023
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Nearly 25% of adults with thyroid nodules diagnosed with diabetes

Nearly 25% of adults with thyroid nodules diagnosed with diabetes

Nearly one-quarter of adults with documented thyroid nodules also have diabetes, according to a study published in the Journal of Clinical Medicine Research.

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June 02, 2023
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Semaglutide may reduce risk for atherosclerotic CVD among adults with obesity

Semaglutide may reduce risk for atherosclerotic CVD among adults with obesity

Adults with obesity who used semaglutide for weight loss reduced their 10-year risk for atherosclerotic cardiovascular disease, according to findings presented at the European Congress on Obesity.

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June 01, 2023
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Semaglutide linked to significant weight loss in adults with obesity in real-world study

Semaglutide linked to significant weight loss in adults with obesity in real-world study

Adults with overweight or obesity receiving semaglutide lost 13.4% of their body weight at 1 year, according to findings from a real-world study presented at the European Congress on Obesity.

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May 18, 2023
4 min read
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Lipoprotein(a): The next frontier in CV risk reduction

Lipoprotein(a): The next frontier in CV risk reduction

This installment of Pipeline Pulse focuses on a single cardiovascular risk factor, lipoprotein(a), and examines two CV outcomes trials aimed at reducing CV events through Lp(a) reduction.

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May 04, 2023
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Most adults with FH do not reach guideline-recommended cholesterol targets

Most adults with FH do not reach guideline-recommended cholesterol targets

About 75% of adults with heterozygous familial hypercholesterolemia do not meet guideline-recommended LDL treatment targets, whereas women with familial hypercholesterolemia are less likely than men to be appropriately treated, data show.

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April 12, 2023
1 min read
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Trial stopped early due to success of statins for CVD prevention in people with HIV

Trial stopped early due to success of statins for CVD prevention in people with HIV

The NIH announced a trial it is funding has been stopped early because an interim analysis found daily statin use greatly prevented major adverse CV events in people living with HIV.

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March 23, 2023
9 min read
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Supplements touting CV benefits may be ‘harmful distraction’ from proven solutions

Supplements touting CV benefits may be ‘harmful distraction’ from proven solutions

Dietary supplements are big business in the United States and elsewhere, especially when it comes to products marketed to support CV health.

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