Among ICU patients, invasive ventilation was used less in Asian, Black and Hispanic patients vs. white patients, according to results published inAnnals of the American Thoracic Society.
“Adoption of strategies to mitigate implicit bias and physiologic thresholds to guide decision-making may help reduce differences in rates of invasive ventilation by patient race and ethnicity,” Fred M. Abdelmalek, of the faculty of medicine at the University of Toronto, and colleagues wrote.
In a multicenter cohort study, Abdelmalek and colleagues analyzed 38,258 ICU patients (median age, 68 years; 46% women) who received oxygen in the first 24 hours of admission to determine if invasive ventilation use differs based on patient race and ethnicity in a model accounting for baseline and time-varying covariates.
Researchers also evaluated how different rates of invasive ventilation mediated changes in 28-day mortality.
Patients in this study came from one of two databases: Medical Information Mart for Intensive Care IV (n = 20,032) and Phillips eICU (n = 18,226).
Most of the total cohort was white (81%), followed by Black (11%), Hispanic (5%) and Asian (2%).
Almost all patients used nasal prongs (95%), whereas only a small percentage of patients used high flow nasal cannula (5.2%).
Within the entire study population, 3,511 (9.2%) patients received invasive ventilation.
When comparing white patients with patients of other racial and ethnic groups, researchers found a decreased rate of invasive ventilation use among Hispanic (adjusted HR = 0.7; 95% credible interval [CrI], 0.61-0.79), Black (aHR = 0.78; 95% CrI, 0.71-0.86) and Asian (aHR = 0.82; 95% CrI, 0.7-0.95) patients.
Of the total cohort, 2,869 (7.5%) patients died, and mortality among the assessed racial and ethnic groups was similar following adjustment.
Researchers did not observe differences in 28-day mortality odds as a result of less invasive ventilation use in the average patient; however, the odds for mortality did differ based on invasive ventilation rate in patients on high-flow nasal cannula with inspired oxygen fraction of one (severe hypoxemia).
In this group of patients, the likelihood for mortality went down among Asian (OR = 0.97; 95% CrI, 0.91-1.03), Black (OR = 0.96; 95% CrI, 0.91-1.03) and Hispanic (OR = 0.94; 95% CrI, 0.89-1.01) patients when the invasive ventilation rate was identical to that of white patients.
“Additional studies incorporating more comprehensive social determinants of health data would help clarify the association between patient race and ethnicity and invasive ventilation use,” Abdelmalek and colleagues wrote.