Suppression antibiotics may improve survival in patients with PJI, retained hardware
Click Here to Manage Email Alerts
Key takeaways:
- Treatment failure occurred in 26.8% of patients during the follow-up period.
- Patients who received more than 2 years of suppression antibiotics had improved survival vs. those who did not receive suppression.
Results presented at the Musculoskeletal Infection Society Annual Meeting showed suppression antibiotics may improve survival rates for patients with a prosthetic joint infection of the hip or knee with retained hardware.
Marjorie Golden, MD, FACP, AAHIVS, associate professor of medicine at the Yale School of Medicine, and colleagues retrospectively analyzed data from 71 patients with a first PJI of the hip or knee managed with debridement and implant retention (DAIR) at the Yale New Haven Hospital between September 2017 and December 2021. Following the DAIR, 77.5% of the cohort received suppression antibiotics.
Outcome measures included treatment failure during the 2-year follow-up period and the role of suppression antibiotics duration on failure rates.
According to Golden, 26.8% of the patient population had treatment failure during the 2-year follow-up period. In addition, Golden said patients who received more than 2 years of suppression antibiotics had statistically significant improvement in survival rates vs. patients who did not receive suppression antibiotics.
“It is likely that select patients diagnosed with PJI of the hip or knee who are managed with retained hardware may benefit from suppressive therapy, but further research is needed to delineate optimal duration of therapy and identify the characteristics of the patients who would derive the most benefit,” Golden concluded.
Collapse
Golden M, et al. Paper 1255. Presented at: Musculoskeletal Infection Society Annual Meeting; Aug. 2-3, 2024; Durham, North Carolina (hybrid meeting).
Read more about
Click Here to Manage Email Alerts