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Improvements seen with microfracture, autologous matrix-induced chondrogenesis for chondral defects
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Short-term clinical improvements were seen with both microfracture and autologous matrix-induced chondrogenesis techniques in patients with chondral defects due to femoroacetabular impingement, according to recently published results.
Researchers identified 109 patients surgically treated at least 8 years before enrollment for acetabular grade III and IV chondral lesions that measured 2 cm2 to 8 cm2. Investigators compared 50 patients treated with microfracture and 59 patients treated with autologous matrix-induced chondrogenesis. Outcomes were evaluated with the modified Harris hip score (mHHS) at 6 months and yearly thereafter for 8 years and with a patient-acceptable symptomatic state analysis.
Results showed at 6 to 12 months, the mHHS significantly improved in both patient groups from 46 to 78, even for lesions greater than 4 cm2. At 2 to 8 years, investigators noted the mHHS was better in patients treated with autologous matrix-induced chondrogenesis compared with patients treated with microfracture. Patients treated with autologous matrix-induced chondrogenesis maintained their mHHS improvement through the 8-year follow-up period; however, the improvement deteriorated after 1 year in patients treated with microfracture.
Total hip arthroplasty was need in 11 patients treated with microfracture. No patients treated with autologous matrix-induced chondrogenesis required THA. There was a short-term improvement seen regarding the patient-acceptable symptomatic state analysis; however, significant degradation was seen at 2 to 8 years in patients treated with microfracture. –by Monica Jaramillo
Disclosures: de Girolamo reports she is paid consultant for Lipogems, RegenMed and Geistlich and receives payment for lectures and receives payment for manuscript preparation from Geistlich. Please see the full study for a list of all other authors’ relevant financial disclosures.
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