Collagenase injections for Dupuytren’s contracture seen as safe with anticoagulation

BOSTON — Results presented at the American Society for Surgery of the Hand Annual Meeting showed collagenase injections for Dupuytren’s contracture were safe in patients who were anticoagulated, regardless of the type of anticoagulation.

Shelley S. Noland

Shelley S. Noland, MD, and colleagues retrospectively reviewed 388 injections performed in 197 patients with Dupuytren’s contracture between 2010 and 2017.

“Of the 388 injections, 201 of these patients were anticoagulated at the time of injection for a percentage of 52%,” Noland said in her presentation here.

She noted 91% of patients who were anticoagulated were taking aspiring, 13% were taking warfarin and 11% were taking additional prescription anticoagulants. Patients had a skin tear rate of 11% and a lymphadenopathy rate of 5%, according to Noland, with no significant difference between the anticoagulated and non-anticoagulated groups.

“We did experience one tendon rupture in a small finger in a patient taking aspiring and no tendon ruptures in the not-anticoagulated group,” Noland said. “This was still not a significant difference between the two groups.”

When Noland and her colleagues placed patients taking aspirin in the non-anticoagulated group, they found no significant differences in complication rates of skin tears, tendon ruptures or lymphadenopathy between the two groups.

“We then did a head-to-head analysis of aspirin vs. prescription anticoagulation and, again, we noted no significant difference in the complication rates between these two groups,” Noland said. “No patients experienced sensor abnormalities, a hematoma requiring intervention or uncontrollable bleeding.” – by Casey Tingle

Reference:

Noland SS, et al. Paper 65. Presented at: American Society for Surgery of the Hand Annual Meeting; Sept. 13-15, 2018; Boston.

Disclosure: Noland reports no relevant financial disclosures.