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Bacteremia may increase risk of developing subsequent PJI
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Compared with previous studies, results published in The Journal of Arthroplasty showed patients with multiple prosthetic joints had a lower risk of developing a subsequent periprosthetic joint infection, with bacteremia at the time of PJI identified as an important factor for developing subsequent periprosthetic joint infection.
Researchers identified bacteremia, risk factors for periprosthetic joint infection (PJI) and time between initial and subsequent infection among 167 patients treated surgically for PJI between 2003 and 2014.
At the time of initial infection, results showed 76 patients had multiple prosthetic joints. Of this subgroup of patients, 13% developed a PJI in a second location. Researchers found a rate of metachronous PJI of 8.3% after they eliminated simultaneous infections.
Compared to 18.1% of patients with a single infection, 70% of patients with multiple infections were bacteremic at the time of initial infection. Researchers noted a patient had a risk of developing an infection in a second joint of 20% and 5.2% if bacteremic or not, respectively.
Results showed chronic renal failure, tobacco use, autoimmune disease or corticosteroid use were risk factors in 60.6% of patients who had a single PJI. Of the 22 different organisms isolated in joint culture from the initial PJI, the most common infectious organism was from a staphylococcal species, followed by culture negative PJI and coagulase-negative staphylococcus PJI. – by Casey Tingle
Disclosures: Abblitt reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.
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