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Use of cell-free osteochondral scaffold clinically improved patellar cartilage defects
Patients with patellar cartilage defects treated with a cell-free collagen-hydroxyapatite osteochondral scaffold experienced clinical improvement at short-term follow-up, according to results.
At 12 months and 24 months, researchers prospectively performed clinical evaluation using IKDC and Tegner scores on 34 patients with knee chondral or osteochondral lesions of the patella treated with a cell-free biphasic collagen-hydroxyapatite osteochondral scaffold (Maioregen; Fin-Ceramica Faenza SpA). Using the magnetic resonance observation of cartilage repair tissue (MOCART) score and specific subchondral bone parameters, researchers also performed MRI evaluation at both follow-ups for 18 lesions.
Compared with basal evaluation, results showed a statistically significant improvement in all scores at 12-months and 24-months follow-up. Researchers found improvement in the IKDC subjective score from approximately 39.5 to 61.9 at 12 months, which further increased to approximately 67.6 at 24-month follow-up.
A stable value of the MOCART score between 12 months and 24 months was shown on MRI evaluation. Investigators found complete filling of the cartilage in 87% of the lesions, complete integration of the graft in 95.7% and intact repair tissue surface in 69.6% at final follow-up. Researchers found the presence of osteophytes or more extensive bony overgrowth in 47.8% of patients. However, results showed no link between MRI findings and clinical outcome. – by Casey Tingle
Disclosures: Perdisa reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.