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Greater number of mesenchymal stem cells released with fibrous synovium in culture model
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Investigators of this study found fibrous synovium compared with adipose synovium release a greater number of mesenchymal stem cells in a suspended synovium culture model.
Researchers harvested human synovial tissue from knee joints during the total knee arthroplasty of 34 patients with osteoarthritis. Investigators suspended 1 gram of synovium with a thread in a bottle filled with 40 mL of culture medium. A 3.5-cm diameter culture dish was at the bottom of the bottle and investigators examined the culture dish after 7 days. Multipotentiality and surface epitopes were analyzed for the cells harvested. Investigators compared the number of colonies derived from the fibrous synovium and the adipose synovium.
In all 28 knees, investigators saw colonies of spindle-shaped cells. Investigators noted, on average, colonies numbered 26 and multipotentiality for chondrogeneis, adipogenesis, calcification and surface epitopes similar to mesenchymal stem cells were seen in the cells derived from colony-forming cells. Fibrous synovium compared with adipose synovium had a significantly greater number of colonies. – by Monica Jaramillo
Disclosures: Katagiri reports no relevant financial disclosures. Please see the full study for list of all other authors’ relevant financial disclosures.
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