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Early anti-inflammatory treatment may help prevent post-traumatic OA after ACL injury
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Recently published results showed early intervention with an anti-inflammatory agent may help prevent some of the changes associated with post-traumatic osteoarthritis after ACL injury.
Christian Lattermann, MD, and colleagues randomly assigned 49 patients with ACL injury to receive corticosteroid at 4 days after ACL injury and a placebo injection of saline at 2 weeks (group 1); a placebo injection at 4 days and then a corticosteroid injection at 2 weeks (group 2); a corticosteroid injection at both time points (group 3); or a saline injection at both time points (group 4). Researchers collected patient-reported outcome measures and synovial biomarkers at approximately 4 days, 11 days and 5 weeks after injury.
Results showed patients had no adverse events or infections. Regardless of treatment group, researchers noted chondrodegenerative markers worsened during the first 5 weeks, except for matrix metalloproteinase-1 and tumor necrosis factor-inducible gene 6, while all patient-reported outcomes improved during this time. Although patients who received corticosteroid injections and the placebo group had no differences in patient-reported outcomes, according to results, the placebo group had a significantly greater increase in C-telopeptide of type II collagen, which was linked with collagen type II breakdown, within the first several days after injury vs. either of the groups that received corticosteroid injection. – by Casey Tingle
Disclosures: Lattermann reports he is a paid consultant for Cartiheal and Vericel and receives research support from Smith & Nephew. Please see the full study for a list of all other authors’ relevant financial disclosures.
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