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Arthroscopic rotator cuff repair augmented with collagen implant had biocompatibility at 6 months
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Patients who underwent arthroscopic rotator cuff repair augmented with a collagen implant overlay had cellular incorporation, tissue formation and maturation, implant resorption and biocompatibility at 6-month follow-up, according to results.
Researchers obtained biopsies of collagen implant/host-tissue constructs from seven patients undergoing a second arthroscopic procedure from 5 weeks to 6 months after arthroscopic rotator cuff repair augmented with a collagen implant overlay. Researchers examined biopsy specimens histologically for host-tissue ingrowth, host-tissue maturation and host-implant biocompatibility.
Results showed the interstices of the porous collagen implant had the presence of host cells at 5 weeks. Researchers found the collagen implant structure had cells aligned along the linear orientation, as well as evidence of early collagen formation. At 3 months, researchers noted the surface of the implant had increased collagen formation, maturation and organization. There was also evidence of the collagen implant, according to results.
The newly generated tissue had the histologic appearance of a tendon at 6 months, results showed, which suggested functional loading of the new generated host tissue. At 6 months, researchers found no evidence of any remnants of the collagen implant, as well as no evidence of any inflammatory or foreign body reaction within any of the tissue samples.
“This is a breakthrough study, as it is the first to show that the Rotation Medical bioinductive implant promotes the rapid growth of tendon-like tissue in humans,” study co-author Steven P. Arnoczky, MD, director of the Laboratory for Comparative Orthopaedic Research at Michigan State University, said in a press release from Rotation Medical Inc. “While clinical studies have demonstrated evidence of new tissue generation via imaging, the histologic character of this tissue could only be inferred. The unique opportunity to evaluate biopsies from implant recipients confirms the findings of the preclinical animal study, and demonstrates that the implant is biocompatible and promotes new connective tissue with the histological appearance of tendon over the surface of the native cuff tendon.” – by Casey Tingle
Disclosures: Arnoczky reports he receives support from Rotation Medical Inc. Please see the full study for a list of all other authors’ relevant financial disclosures.
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