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Greater likelihood of healing seen with antibiotic-loaded collagen granules as dressing agent vs EUSOL
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NATIONAL HARBOR, Md. — According to a speaker at the Orthopeadic Trauma Association Annual Meeting, the use of antibiotic-loaded collagen granules as a dressing agent for infected wounds was a more cost-effective method and had better quality granulation tissue than the use of Edinburgh University Solution of Lime.
“The healing potential in the wounds dressed with collagen granules with antibiotics has a one in five-times better healing potential in comparison to [the] usual,” Rajiv Maharjan, MBBS, MD, said during his presentation.
Maharjan and colleagues included 130 patients with infected traumatic limb wounds and surgically infected wounds. Sixty-five patients were randomized to be treated with the Edinburgh University Solution of Lime (EUSOL), and the remaining 65 patients were treated with mupirocin in collagen granules and metronidazole (Co-Mupimet). Investigators collected a wound swab for culture at the time of presentation. Measurements for the size of the wound following debridement were taken at first presentation and then at 1 week, 2 weeks, 3 weeks and 4 weeks, and investigators also assessed the quality and quantity of granulation tissue formation.
Results showed groups did not have significant differences regarding distribution of gender, distribution of injury mode, injury spectrum or ratio of culture positives at presentation. Maharjan and colleagues noted wounds dressed with the antibiotic-loaded collagen granules had a lesser amount of discharge. At 1 week, 2 weeks, 3 weeks and 4 weeks, patients treated with EUSOL had a probability of compete healing of 0.16, 0.29, 0.41 and 0.5, respectively. In patients treated with antibiotic-loaded collagen granules the probabilities were 0.26, 0.61, 0.61 and 0.4, respectively. The corresponding odds ratios were 1.62, 2.1, 1.48 and 0.8, respectively.
“If you compare the final outcomes at day 7, 2 weeks, 3 weeks and 4 weeks, we found the P value is significantly different at 2 weeks and 3 weeks,” he said. “So we assume the healing potential is more in comparison to [the] usual in the mupirocin [in] collagen granules group.” – by Monica Jaramillo
Reference:
Maharjan R. Paper #29. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 5-8, 2016; National Harbor, Md.
Disclosure: Maharjan reports no relevant financial disclosures.