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Rotator cuff repair failures may be more common in patients with a family history of tears
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Patients who underwent rotator cuff repair were more likely to have repair failures if they had a family history of rotator cuff tears, according to results.
At a minimum of 1 year postoperatively, researchers performed MRI on 72 patients who underwent arthroscopic rotator cuff repair for a full-thickness posterosuperior tear and classified any failures as lateral or medial. Researchers compared characteristics of cases with vs. without a family history of rotator cuff tears and performed a comparison for the frequency of single-nucleotide polymorphism 1758384 in estrogen-related receptor beta gene between patients who healed and patients who failed to heal.
Robert Z. Tashjian
Results showed 42% of patients had a positive family history of rotator cuff tears and 42% of all rotator cuff tears examined in the study failed to heal. Among patients who had lateral failures, researchers found a significantly larger tear size compared with patients who had tears that healed.
According to multivariate regression model, failure to heal was independently associated with family history and greater tear retraction. Researchers also found, among patients with a family history of tearing, the larger the tear size, the higher the risk of failure. Results showed an independent association between family history and worse healing, with patients who had a family history of cuff tears with a larger tear size showing a higher risk of lateral healing failure. Compared with rotator cuff tears that healed, patients with lateral failures had an increased risk for the presence of a rare allele for single-nucleotide polymorphism rs17583842. – by Casey Tingle
Disclosure: The researchers report no relevant financial disclosures.
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