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Synovial fluid biomarkers may predict clinical outcomes after knee arthroscopy
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Before patients undergo knee arthroscopy, synovial fluid biomarkers can reflect the intra-articular environment and potentially predict postoperative clinical outcomes, according to results.
Researchers obtained synovial fluid samples from 81 patients undergoing knee arthroscopy, including 70 samples from operative knees and 32 samples from contralateral knees. Researchers collected preoperative baseline data from clinical questionnaires, including the VAS, Lysholm and KOOS–Physical Function Short Form, and documented intraoperative findings, procedures performed and ICRS cartilage status scores in all operative knees. Using a multiplex magnetic bead immunoassay, researchers measured the concentrations of 20 biomarkers.
Eric J. Strauss
Results showed strong positive correlations between the ICRS score and age, symptom duration, VAS and KOOS–Physical Function Short Form scores. Monocyte chemotactic protein-1 had a strong positive correlation with interleukin (IL)-6 concentrations, intraoperative ICRS score and continued pain at the time of final follow-up, according to results.
Researchers found the strongest predictors of severe cartilage lesions were monocyte chemotactic protein-1 and IL-6, while the IL-1 receptor antagonist was inversely related. In all operative samples, results showed matrix metalloproteinase-3 levels were consistently elevated, as well as directly correlated to increased preoperative VAS scores. Researchers noted the strongest predictors of postoperative improvement at final follow-up included regulated upon activation normal T-cell count expressed and secreted (RANTES), vascular endothelial growth factor and platelet-derived growth factor BB, regardless of injury and cartilage status. – by Casey Tingle
Disclosures: Cuéllar receives support from Cytonics. Please see the full study for a list of all other authors’ relevant financial disclosures.
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