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Benefits of preoperative autologous blood donation for adult spinal deformity remain unknown
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Researchers of this study found no protective effect of preoperative autologous blood donation against allogenic blood exposure for patients who underwent single-stay, adult spinal deformity surgery.
Researchers compared patients who underwent preoperative autologous blood donation (PABD) with patients who had no PABD prior to single-stay, adult spinal deformity (ASD) surgery. Researchers identified 60 patients treated with PABD, of whom 50 patients were matched to 50 patients who were not treated with PABD.
According to researchers, one-third of PABD patients did not receive any autologous blood transfusions and the donated blood was wasted. Six of these patients received allogenic blood transfusions without autologous donations. In addition, nine patients received allogenic and autologous blood transfusions.
Rates of perioperative major and minor complications were similar between the groups. Researchers found 10% of PABD patients experienced major complications compared with 12% of patients in the no PABD cohort. Also, 30% of PABD patients experienced minor complications compared with 24% of patients in the no PABD cohort.
After controlling for potential confounders, researchers noted PABD patients were more likely to receive a transfusion. Researchers did not note a connection between PABD and allogenic blood exposure, which they noted refutes the concept that PABD is protective against allogenic (ALLO) blood exposure.
“This study supports the concept that PABD may not be effective in ASD, as 25% of patients were exposed to ALLO blood, 30% of cases received no transfusion, and, in a propensity-matched cohort, PABD did not protect against ALLO blood exposure. This is probably due to the large [estimated blood loss] EBL associated with these procedures and the inability of patients to donate a quantity sufficient to protect against transfusions of ALLO blood,” the researchers wrote in the study. – by Robert Linnehan
Disclosures: Kelly reports research support from OREF, AOSpine, Barnes Jewish Foundation and the Cervical Spine Research Society. Please see the full study for a list of all other authors’ relevant financial disclosures.
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