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Higher cortical pore volume found in men, women with diabetes
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Men with diabetes experienced higher cortical porosity and cortical pore volume at the distal tibia, while women with diabetes experienced higher cortical pore volume at the distal radius, according to results.
Researchers performed high-resolution peripheral quantitative CT scans on 332 participants either with or without diabetes to study associations between bone microarchitecture of the distal radius and the distal tibia.
At the distal radius, researchers found men with diabetes had a higher trabecular number and cortical porosity and a lower cortical density and trabecular separation compared with men without diabetes. Results also showed cortical porosity, cortical pore volume and trabecular number were higher and cortical density and trabecular separation were lower at the distal tibia in men with diabetes. Women with diabetes experienced higher cortical porosity and cortical pore volume at the distal radius vs. women without diabetes, according to results. Women with type 2 diabetes had higher cortical pore volume, while cortical porosity was close to the margin of statistical significance.
“This study highlights an important link between diabetes and osteoporosis, and identifies a selective deficit in skeletal development, which leads to excess fracture risk in this increasingly frequent disorder,” Cyrus Cooper, a coauthor of the study, said in a press release. “It also demonstrates that environmental influences during critical periods of early development might lead to several common non-communicable disorders in western populations.” – by Casey Tingle
Disclosures: Paccou reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.
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