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Patients with OA, certain genotypes had more pain variability
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More variability in day-to-day pain and exacerbation of pain after daily physical activity was experienced among patients with osteoarthritis and certain genotypes for catechol-O-methyltransferase and mu-opioid receptor compared with patients who had other genotypes, according to results.
Using handheld computers, 120 patients with knee osteoarthritis (OA) reported on their pain three times a day during 22 days. Patients also wore an accelerometer to capture daily physical activity. Researchers examined the magnitude of within-person variability in pain by genetic group using multilevel modelling, as well as whether lagged, within-patient associations between level of activity in the afternoon and knee pain at the end of the day were moderated by between-patient differences in genotype.
Results showed patients with two copies of the Asn40 allele of mu-opioid receptor had the greatest day-to-day pain variability, while patients with the Val/Val genotype of catechol-O-methyltransferase had the greatest pain variability, as well as the greatest increase in pain as a result in physical activity. Researchers found consistencies between a similar pattern of findings across bi-directional lags with a negative feedback loop between daily physical activity and pain according to genotype. When comparing patients according to catechol-O-methyltransferase or mu-opioid receptor, results showed no significant between-person differences for daily pain. – by Casey Tingle
Disclosure: The researchers report no relevant financial disclosures.
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