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More recent years show decreased proportion of reported malignant giant cell tumors in Sweden
Results of this population-based study indicated a higher proportion of malignant giant cell tumors as recorded in Swedish Cancer Registry data from 1958 to 1982 compared with reports from 1983 to 2011.
Using the Swedish Cancer Registry and ICD codes, researchers identified 4,625 bone tumors between 1958 and 2011. Of these, 505 were giant cell bone tumors and 1,152 were osteosarcomas. Results showed the ratio of benign giant cell tumors was 1.3 from 1958 to 1982 and dropped to 0.09 from 1983 to 2011. The researchers wrote, this suggests “a change in the reporting or diagnosis of malignant or benign cases.”
An age and gender distribution was shown among cases of giant cell tumor diagnosed from 1983 to 2011 and were consistent with distributions reported in large published case series, according to the study. However, results showed the distributions differed from those in 1958 to 1982. Researchers found current data showed a giant cell tumor incidence in Sweden of 1.3 per million per year and an osteosarcoma incidence of 2.3 per million per year. – by Casey Tingle
Disclosures: Rockberg received personal fees from Amgen Inc. Please see the full study for a list of all other authors’ relevant financial disclosures.