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Acetabular protrusio linked to increased fracture risk among patients with osteogenesis imperfecta
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About half of the patients in this study with osteogenesis imperfecta had acetabular protrusio, and the condition was more commonly seen in patients with type III osteogenesis imperfecta. Moreover, investigators found that compared to patients with normal hip anatomy, patients with acetabular protrusio had a 30% increased risk for proximal femur or acetabular fractures.
Researchers retrospectively reviewed the cases of 49 patients with osteogenesis imperfecta (OI) who had a mean age of 20.1 years, and had either hip-to-ankle or anteroposterior radiographs. Previously published radiographic criteria, such as the acetabulum relative to Kohler’s line, were used to diagnosis acetabular protrusio.
Using radiographic criteria, investigators found 27 patients had acetabular protrusio, with most incidences seen in patients with type III OI (70.6%). Patients with type I and type IV OI had acetabular protrusio rates of 35.7% and 45.5%, respectively.
Investigators also found patients with acetabular protrusio had a 30% increased chance for proximal femur fractures and acetabulum fractures compared with patients who had normal hip anatomy (29.6% vs. 4.5%). Researchers noted OI type may have been a confounding variable in the study; but, they found no statistically significant association between acetabular protrusio and OI type. ‒ by Monica Jaramillo
Disclosures: The researchers report no relevant financial disclosures.
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