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Hip arthroscopy revealed abnormal full-thickness acetabular chondral flaps
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The biochemical properties and number of live chondrocytes for full-thickness chondral flaps sampled during hip arthroscopy indicated these chondral flaps were not normal and had a degenerative appearance based on results of a biomechanical analysis.
Researchers collected 21 full-thickness acetabular chondral flaps during hip arthroscopy performed in 20 patients and performed a biomechanical analysis of the flaps, which looked at DNA, hydroxyproline and glycosaminoglycan concentrations. Using 10 flaps they retrieved from 10 patients the researchers also studied chondral flap cellular viability.
Results of these analyses showed concentrations within one standard deviation of the mean values reported in previous studies of normal cartilage of 38% for DNA, 0% for glycosaminoglycan and 43% for hydroxyproline in the acetabular chondral flap specimens.
There was 39% or average cellular viability for the acetabular chondral flap specimens and more than half the cells were still viable in two of the 10 specimens.
Results showed no correlation between the gross examination of the joint or knowledge of the patient’s demographic characteristics and symptoms, as well as between biochemical properties and cell viability of the flap. However, researchers found a degenerative appearance of the surrounding cartilage that correlated with a higher hydroxyproline concentration. – by Casey Tingle
Disclosure: Hariri reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.
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