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No association found between secondary osteosarcoma, chondroblastic subtype
No association was found between secondary osteosarcoma and chondroblastic subtype, according to study results.
Researchers performed a retrospective chart review and identified 131 cases of osteosarcoma treated from 1991 to 2012. A pathologist evaluated histologic subtypes, and the researchers performed a literature review to identify the histological subclassification of additional series of secondary osteosarcomas.
Among the cases identified, nine (6.9%) had secondary malignancy, according to the researchers. Results showed six of these cases (67%) had some degree of chondroid differentiation; two cases (22%) had the chondroblastic variant, and one of the nine cases identified (11%) had the telangiectatic variant. None of the tumors studied had the fibroblastic variant.
Lor Randall
The researchers identified two of three cases meeting the criteria for post-radiation osteosarcoma identified as chondroblastic variants, but all three had some degree of chondroid differentiation.
In the literature review, five studies evaluating histologic subtypes in post-radiation osteosarcoma showed a cumulative frequency of 20% for the chondroblastic variant, according to study results. – by Casey Tingle
Disclosure: The researchers report no relevant financial disclosures.