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MACI, novel treatment clinically valid for femoroacetabular impingement

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CHICAGO — For the treatment of cartilage defects resulting from femoroacetabular impingement, both matrix autologous chondrocyte implantation and autologous matrix-induced chondrogenesis presented as clinically valid treatment options, according to a presenter here.

“It is safe to conclude the arthroscopic MACI [matrix autologous chondrocyte implantation] and AMIC [autologous matrix-induced chondrogenesis] both present clinically valid options for treating cartilage defect resulting from FAI [femoroacetabular impingement], with clear advantages for AMIC,” Andre J. Fontana, MD, said in his presentation at the International Cartilage Repair Society Annual Meeting.

Using the modified Harris Hip Score, Fontana and colleagues pre- and postoperatively assessed 80 patients who underwent MACI and 62 patients who underwent AMIC for treatment of chondral defects of the hip due to FAI. Patients ranged in age from 18 years to 51 years, and the average lesion size was 3.6 cm².

Fontana noted similar baseline modified Harris Hip Scores, mean postoperative modified Harris Hip Scores and mean improvement at the end of the study for all groups.

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By the end of the study, results showed a mean modified Harris Hip Score of 81.1 in patients who underwent MACI with hyaluronic acid scaffold, 80.1 in patients who underwent MACI with polymer scaffold and 84 for patients who underwent AMIC. Change in mean modified Harris Hip Score from baseline to the end of study was 36.4 for MACI with hyaluronic acid scaffold, 35.7 for MACI with polymer scaffold and 39.4 for AMIC.

Fontana noted the greatest improvements were observed in the first 6 months and up to 1 year after surgery, and that improvements were maintained overtime until the end of the study. – by Casey Tingle

Reference:

Fontana A. Arthroscopic AMIC or MACI for the treatment of acetabular chondral defects secondary to FAI. Presented at: International Cartilage Repair Society Annual Meeting. May 8-11, 2015; Chicago.

Disclosure: Fontana reports no relevant financial disclosures.