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Use of Harvest system resulted in greater connective tissue progenitor number, concentration
After centrifugation, the Harvest system resulted in greater connective tissue progenitor number and concentration and may provide increased osteogenic and chondrogenic capacity compared with the Biomet and Arteriocyte systems, according to study results.
Among 40 patients prospectively consented for bilateral iliac crest aspiration, researchers compared the Harvest and Biomet systems in the first 20 aspirations and the Harvest and Arteriocyte systems in the second 20 aspirations.
The researchers randomly assigned one system to each iliac crest and followed each system’s unique marrow acquisition process and centrifugation mechanism. Samples were taken before and after the marrow was put into the centrifugation system, and the researchers estimated the number of progenitor cells by counting the connective tissue progenitors (CTPs).
Study results showed, when compared with the Biomet system, the Harvest system achieved a significantly greater number and concentration of CTPs both before and after centrifugation. However, no difference in the percent yield of CTPs was found after centrifugation, according to the researchers.
Although the researchers found no significant difference in the number and concentration before centrifugation between the Harvest and Arteriocyte systems, a significantly greater number and concentration of CTPs, as well as a significantly higher percent yield of CTPs, was seen with the Harvest system after centrifugation.
Disclosures: Ellis is a consultant to Orthohelix. Lane is a consultant for Amgen, Zimmer, Grafty’s, Bone Therapeutics SA and Collplant and has received grants from Eli Lilly, Novartis, Warner and Chilcott.