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Practical applications of biologics: Searching for clear indications
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In recent years, there has been increasing interest in strategies to augment the biology of soft tissue healing. Improved understanding of the cellular and molecular mechanisms of tissue degeneration and the limitations in healing and regeneration of musculoskeletal connective tissues have suggested the need for approaches to augment the basic biology of tissue repair. Advances in the understanding of stem cell biology, the role of cytokines and inflammatory mediators in tissue healing and degeneration, gene transfer techniques and the discovery of novel biomaterials suggest tremendous potential to augment the biology of soft tissue repair. The challenge is to continue well-designed translational research studies to bring these techniques to clinical fruition.
In this Orthopedics Today Round Table, Scott A. Rodeo, MD, asks several individuals with expertise in connective tissue healing to comment on the current status and future potential of various approaches for augmentation of healing. Click here to read more.