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Preoperative teriparatide treatment increases pedicle screw insertional torque
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The use of teriparatide injections at least 1 month prior to surgery effectively increased the insertional torque of pedicle screws during fusion surgery among postmenopausal women with osteoporosis, according to the results of a study.
Twenty-nine postmenopausal women with osteoporosis who underwent fusion surgery for the thoracic and/or lumbar spine were included in the study. Researchers divided the patients into two groups, among whom 13 were treated preoperatively with teriparatide and 16 were not. Patients in the teriparatide group received the therapy either daily at 20 µg/day or weekly at 56.5 µg/week; treatment with teriparatide lasted for a mean of 61.4 days and a minimum of 31 days. The researchers measured the insertional torque during surgery for 212 screws inserted from the T-7 to T-5 levels and compared measurements between the two groups.
In the teriparatide group, the mean insertional torque value was 1.28 Nm, which was statistically significantly higher than the 1.08 Nm seen in the control group, according to the researchers.
No significant differences with regard to mean insertional torque value were noted between the daily or weekly treatment groups, and a negligible correlation between duration of treatment and insertional torque was observed by the researchers.
Disclosure: No relevant financial disclosures were reported.
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