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Minimal link seen between clinical and radiologic outcomes following MACI
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Recently published study data demonstrated little evidence linking clinical and radiologic outcomes following matrix-induced autologous chondrocyte implantation to treat chondral defects of the knee, according to researchers.
Researchers conducted a retrospective study of 83 patients who underwent matrix-induced autologous chondrocyte implantation (MACI). Full clinical and radiological follow-up took place at 1, 2 and 5 years postoperatively using KOOS and MRI, respectively. The Spearman correlation coefficient was utilized to determine any association between MRI parameters and KOOS subscales postoperatively.
According to the researchers, effusion was the only MRI parameter that showed a consistent association with KOOS subscales, as a pattern of increasing strength of correlations over time and statistically significant associations with KOOS-pain, KOOS–activities of daily living and KOOS-sport were observed at 5-year follow-up.
The only other link determined to be of significance was between subchondral lamina and KOOS-Sport at 1 year postoperatively, according to the researchers.
Disclosure: The authors have no relevant financial disclosures.
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