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Neurons undergo molecular changes in the transition from acute inflammatory pain to chronic neuropathic pain

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Mohammed F. Shamji, MD, PhD, FRCSC, spoke about his study “Peripheral Hypersensitivity to Subthreshold Stimuli Persists after Resolution of Acute Experimental Disc-Herniation Neuropathy and is Mediated by Heightened TRPV1 Receptor Expression and Activity,” which was presented at the American Association of Neurological Surgeons Annual Meeting. The researchers found that in the transition from acute inflammatory pain to chronic neuropathic pain, neurons undergo molecular changes. These change, he said, have the potential to cause permanent structural changes to neurons and functional sensitivity in the pain experience.