This article is more than 5 years old. Information may no longer be current.
G-CSF used for acute SCI found beneficial for neurological recovery
Click Here to Manage Email Alerts
Among patients with acute spinal cord injury, administration of granulocyte colony-stimulating factor had beneficial effects on neurological recovery, according to study results published in Spine.
Researchers included 41 patients with spinal cord injury (SCI) treated within 48 hours of onset to two groups, one that received granulocyte colony-stimulating factor (G-CSF; 10 µg/kg/d) intravenously for 5 consecutive days (17 patients) or a control group that underwent similar treatment except for the administration of G-CSF (24 patients). Using the American Spinal Cord Injury Association score and American Spinal Cord Injury Association impairment scale, researchers evaluated the patients’ motor and sensory function at 1 week, 3 months, 6 months and 1 year after onset.
Overall, 2 patients in the G-CSF group and 15 patients in the control group did not show an improvement on the American Spinal Cord Injury Association impairment scale. Researchers detected a significant increase in the American Spinal Cord Injury Association motor score in the G-CSF group from 1 week after the use of G-CSF vs. the control group, which was maintained for one year, according to the results.
The researchers, who are from Japan, noted in the abstract that they observed a spontaneous increase of motor score in some of the control group.
Disclosure: The researchers report no relevant financial disclosures.
Click Here to Manage Email Alerts