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Posterior iliac crest yields higher concentration of mesenchymal stem cells
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Researchers found the posterior iliac crest is superior to the anterior iliac crest regarding concentration and yield for colony-founding connective-tissue progenitors, according to results of this study.
“The harvesting of bone marrow from the posterior iliac crest appears to be preferred, as it provided a modestly higher concentration of colony-founding connective-tissue progenitors than comparable aspirate from the anterior iliac crest,” Michela Pierini, PhD, and colleagues from the Rizzoli Orthopaedic Institute in Bologna, Italy, wrote in the study abstract.
Pierini and colleagues examined marrow aspirate from 22 patients. The researchers used a colony formation assay to analyze concentration and prevalence of colony-founding connective tissue progenitors from posterior and anterior iliac crests.
They found that in the marrow from the posterior iliac crest, colony-founding connective tissue progenitors were 1.6 times greater than in the anterior iliac crest, according to the abstract. Pierni and colleagues noted no significant difference between expansion kinetics, multilineage differentiation potential, viability or phenotype of mesenchymal stem cells from either site.
Disclosure: The authors’ institution received a grant for their work on this study.
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