This article is more than 5 years old. Information may no longer be current.
Preoperative scoring, symptom duration predictive of MACI outcome at 5 years
The mental and physical components of the SF-36 score and duration of symptoms for full-thickness chondral knee defects were significantly associated with improved outcome at 5-year follow-up after matrix-induced autologous chondrocyte implantation, according to this study.
“This study outlined factors such as preoperative SF-36 scores, duration of knee symptoms, graft size and postoperative course of weightbearing rehabilitation as pertinent variables involved in 5-year clinical and radiological outcomes and overall satisfaction,” Jay R. Ebert, PhD, and colleagues wrote in the study abstract. “This information may allow orthopedic surgeons to better screen their patients as good candidates for [matrix-induced autologous chondrocyte implantation] MACI, while allowing treating therapists to better individualize their preoperative preparatory and postoperative rehabilitation regimens for a best possible outcome.”
Ebert and colleagues analyzed 5-year results of 104 patients who underwent MACI for either the tibial or femoral condyles, according to the abstract. The researchers said that, other than symptom duration and SF-36 mental and physical scores, no variable was associated with Knee Injury and Osteoarthritis Outcome Score (KOOS) quality of life score at 5 years.
However, they noted MRI score was predicted by the SF-36 mental component score, symptom duration and graft size. At 5 years, patient satisfaction was significantly associated with an 8-week return to full weightbearing as opposed to a 12-week return, according to the abstract.
Disclosure: The authors received funds from the National Health and Medical Research Council and the Hollywood Private Hospital Research Foundation to conduct this study.