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Accelerated femoral BMD loss in men increases risk for other fracture types
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Older men with an accelerated femoral neck bone mineral density loss have increased risk for hip and other non-spine fractures, according to this study.
Using dual-energy X-ray absorptiometry, researchers from the California Pacific Medical Center in San Francisco measured the bone mineral density (BMD) of 4,470 men 65 years or older with osteoporosis at two to three time points over 4.6 years. They categorized BMD change as either “accelerated,” “expected” or “maintained,” according to the abstract.
“Accelerated decrease in BMD is a strong, independent risk factor for hip and other non-spine fractures in men,” Peggy M. Cawthon, PhD, MPH, stated in the abstract.
Cawthon and colleagues used the measurements to predict the risk of hip, non-spine/non-hip and non-spine fractures in these men during the next 4.5 years. While men with accelerated femoral neck BMD loss had a risk for hip, non-spine/non-hip and non-spine fractures, there was no significant difference in men with expected loss.
While adjusting the data for the initial BMD measure did not change the results, “adjustment for the final BMD measure attenuated the change in BMD-non-spine fracture and the change in BMD-non-spine/non-hip relationships such that they were no longer significant, whereas the change in the BMD-hip fracture relationship was attenuated,” Cawthon and colleagues said.
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