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Study reports long-term outcomes of two-stage protocol for infected TKRs

Macheras. G. A. J Bone Joint Surg (Br). 2011. doi: 10.1302/0301-620X. 93B11. 27319.

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Using a two-stage re-implantation protocol, Greek researchers successfully eliminated infection in 91.1% of patients with chronically infected total knee replacements.

G. A. Macheras, MD, PhD, examined 34 patients with infected total knee replacements who were treated by the same surgical team at a specialist center using a two-stage revision protocal. The investigators isolated a resistant organism in 53% of the patients.

All of the patients were evaluated using the Knee Society Score (KSS) and the American Knee Society Roentgenographic scoring system, and were followed for a mean of 12.1 years.

During the study, one patient died due to an unrelated cause and two patients were lost to follow up. The investigators found that eight patients developed a recurrent infection that required additional surgery, and discovered one case of aseptic loosening at 13 years. The researchers also reported a significant improvement in clinical scores at final follow up.