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Study finds no safety or efficacy issues in continuous warfarin use for total knee arthroplasty patients

Chana R. J Bone Joint Surg Am. 2011. doi:10.1302/0301-620X.93B11.27255

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Researchers found no significant difference in patients receiving long-term warfarin therapy before undergoing total knee arthroplasty compared with patients who did not receive the therapy, according to a recent study.

Patients split into two groups based on warfarin use showed no significant difference in preoperative and postoperative hemoglobin levels, incidence of transfusion or incidence of postoperative complications, according to the abstract.

Between 2006 and 2008, researchers studied 24 consecutive patients receiving warfarin therapy and compared them to a group of similar age and gender ratios who were not taking any anticoagulant medications, according to the abstract. Researchers said there was no significant difference in the range of movement in the two groups 2 days postoperatively. There was a mean 0.4 perioperative fluctuation in the international normalized ratio but the change was minimal and not high enough to delay surgery, according to the abstract.