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Mid-term follow-up shows continued improvement in patients treated with MACI

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MIAMI — Significant clinical improvement can be maintained for up to 5 years in patients treated with matrix-induced autologous chondrocyte (MACI) implantation for full-thickness cartilage defects in the knee, according to Australian research findings presented here.

“We conclude that MACI is a safe and effective treatment in our Western Australian experience,” Simon R. Zilko, MD, said during his presentation at the 8th World Congress of the International Cartilage Repair Society, here. “We have seen a significant improvement in a number of measures given in both the short- and medium-term follow-ups.”

Zilko and his colleagues prospectively studied 44 patients who underwent MACI with a total of 52 implantations. The investigators evaluated the patients for up to 5 years using the Knee Injury and Osteoarthritis Outcome Score (KOOS), SF-36, Visual Analog Scale (VAS) and Knee Pain scales. They also assessed patients’ function using a 6-minute walk test and active range of motion evaluation.

Compared to the patients’ preoperative values, the investigators found a significant improvement in all of the KOOS subscales from either 6 or 12 months to 5 years postoperatively. Similarly, they discovered a significant improvement in Knee Pain and VAS scores from 12 months to 5 years postoperatively.

They also found a significant increase in walk test outcomes between 1 and 3 years, and noted a significant improvement in range of motion from 2 years through 5 years postoperatively. In addition, patient satisfaction scores at 12 months postoperatively remained consistent through 5 years, Zilko said.

Reference:

• Zilko SR, Woodhouse JJ, Smith AJ, et al. A prospective clinical evaluation of matrix-induced autologous chondrocyte implantation (MACI) at 5 years. Paper #15.3.9. Presented at the 8th World Congress of the International Cartilage Repair Society. May 23-26, 2009. Miami.