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Bone-muscle indices did not help predict risk for fracture in men

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TORONTO — Using bone-muscle indices does not appear to assist clinicians in evaluating the risk for fracture in men, according to the results of a recently presented study.

Using data from the Osteoporotic Fractures in Men Study (MrOS), researchers evaluated measures from 1,163 men who completed peripheral quantitative computed tomography (pQCT) scans of the tibia.

“We found that there was no added value in having bone-muscle indices on top of areal bone mineral density [BMD] alone [in predicting fracture risk],” Andy Kin On Wong, HBSc, a PhD candidate in physiology and pharmacology in the department of medical sciences at McMaster University in Ontario, told Orthopedics Today’s sister publication, Endocrine Today.

The researchers found that bone-muscle indices were smaller in men with fractures compared to those without fractures. In addition, men with fractures had weaker grip strength and reduced areal BMD at the total hip and lumbar spine.

After controlling for functional capacity and lumbar spine areal BMD, only bone-muscle-bending indices and bone muscle mass index were significant measures for detecting increased risk for fracture.

The researchers cited several limitations of their study, including its cross-sectional design. Another, Wong said, was that “the MrOS cohort was several thousand, but only two sites had pQCT measurements.”

For future studies, the researchers want to examine the response of bone to muscle and a larger cohort of men.

“For response to be measured, we need to look at it longitudinally,” Wong said. “By looking at the change in bone over muscle, we can see how much bone is responding to muscle changes.” — by Louise Gagnon

Reference:

• Wong AKO. Concurrent oral session 4: Osteoporosis assessment – fracture risk in men. #1021. Presented at: American Society of Bone and Mineral Research 2010 Annual Meeting; Oct. 15-19. Toronto.

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