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Bone fluoride levels not linked with osteosarcoma, study finds

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A study released by the International and American Associations for Dental Research in its Journal of Dental Research reported no significant association between bone fluoride levels and osteosarcoma risk.

In the study, led by researcher Chester W. Douglass, PhD, orthopedists from nine U.S. hospitals identified a cohort of 137 osteosarcoma cases and a cohort of 51 tumor controls between 1993 and 2000. Segments of tumor-adjacent bone and iliac crest bone from these cohorts were then analyzed for fluoride content. The team reported no significant differences between the osteosarcoma and tumor control cohorts with regards to bone fluoride levels.

“The controversy over whether there is an association between fluoride and risk for osteosarcoma has existed since an inconclusive animal study 20 years ago,” International and American Associations for Dental Research Vice President Helen Whelton, PhD, stated in a release.

“Numerous human descriptive and case-control studies have attempted to address the controversy, but this study of using actual bone fluoride concentrations as a direct indicator of fluoride exposure represents our best science to date, and shows no association between fluoride in bone and osteosarcoma risk,” she added.

Reference:

• Kim FM, Hayes C, Williams PL, et al. An assessment of bone fluoride and osteosarcoma. J Dent Res. 2011. doi: 10.1177/0022034511418828

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