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October 19, 2023
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VIDEO: Preservative-free eye drops reduce corneal staining in dry eye disease

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NEW ORLEANS — Research presented at Academy ’23 demonstrated that perfluorohexyloctane, which is indicated for dry eye disease, reduces corneal staining up to four times more than saline.

“This study showed a lot of very favorable results,” Ahmad M. Fahmy, OD, FAAO, Dipl ABO, of Minnesota Eye Consultants, said in this Healio video perspective.

In an analysis of data from two phase 3, multicenter studies of 1,217 adult patients randomized to the preservative-free semifluorinated alkane Miebo (perfluorohexyloctane ophthalmic solution, Bausch + Lomb) or saline, Fahmy and colleagues found that total corneal fluorescein staining improved twofold, central staining improved fourfold, and inferior staining improved more than twofold in the treatment group.

“A lot of us see these patients that struggle with the evaporative component of dry eye disease, and variable vision as we all know is really related to that central corneal staining as well as those patients we see with inferior staining that have exposure,” Fahmy said.