MiSight contact lenses effective for myopia control
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MiSight daily disposable soft contact lenses were effective at slowing myopia progression compared with standard daily disposable lenses, according to study results published in Journal Optometry and Vision Science.
“Myopia represents a growing public health issue, affecting 33% of adults in the United States. ... In the past decade, there has been increased research activity aimed at slowing the progression of myopia by optical methods, including overnight corneal reshaping contact lenses (orthokeratology) and soft contact lenses,” Paul Chamberlain, BSc, CooperVision, and colleagues wrote. “The clinical trial was designed to quantify the effectiveness of the MiSight lenses for slowing juvenile-onset myopia progression.”
Researchers enrolled 144 children with myopia 8 to 12 years old into a multicenter, double-masked, randomized clinical trial. They randomly assigned patients to either MiSight lenses (CooperVision) or control lenses over the duration of 3 years.
Investigators also assessed cycloplegic spherical equivalent refraction (mean error at baseline: 2.02 D in MiSight group vs. 2.19 D in control group) and axial length (mean at baseline: 24.42 mm vs. 24.46 mm, respectively) at baseline and all subsequent follow-up visits.
Study results yielded a 75.5% retention rate (n= 53 MiSight, 56 control) with no serious cases of adverse events. Researchers measured unadjusted change in spherical equivalent refraction at –0.73 D (59%) less in the MiSight group compared with the control group (about –0.51 D vs. about –1.24 D, respectively; P < .001) and mean change in axial length at 0.32 mm (52%) less in the MiSight group compared with the control group (about 0.30 mm vs. about 0.62 mm, respectively; P < .001). They found high correlations among changes in both primary outcomes (r = –0.9; P < .001). They also observed four asymptomatic corneal infiltrative events.
“The progression of refractive error in children is significantly reduced by the MiSight lens compared with a single-vision soft contact lens,” Chamberlain and colleagues concluded. “The axial elongation that underlies and is correlated with refractive error progression is significantly less with the MiSight lens ... and favorable subjective ratings show that contact lens acceptance was sustained across 3 years.”
Perspective
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Tamara Oechslin, OD, PhD, FAAO
MiSight contact lenses are an FDA-approved, class III medical device (available up to –6.00 DS) that we can recommended to patients with myopia to attempt to slow growth of the eye and change in refractive error. This study compares daily disposable contact lenses differing only in optical design between treatment and control group.
Distance and near visual acuities were age-normal with both lenses, yet no data were presented on potential binocular vision side effects from the dual-focus design. The overall results seem to be generalizable across all patient populations with no significant difference in results by ethnicity, age or sex or among sites on three continents. Similar to Proclear 1-day (CooperVision), MiSight lenses are easy to fit (more than 95%), young patients were satisfied with ease of use (more than 90%), and patients wore them for 12 to 13 hours a day (97%). Despite a moderate Dk, there were no significant adverse events, suggesting healthy use in young children. We do not yet know if a post-treatment rebound effect could occur should patients stop wearing these contact lenses. However, the MiSight lenses have shown to be an effective option for myopia control in children 8 to 12 years old with up to –4.00 D spherical myopia.
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