Scoring system showed ability to characterize FA features in children with uveitis
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A standardized quantitative scoring system applied to fluorescein angiography imaging showed the ability to reveal specific findings associated with uveitis location, visual acuity and etiology in pediatric patients.
In a poster presented at Real World Ophthalmology, Sarah Ye and co-authors shared the results of a retrospective study conducted on 137 eyes of 88 pediatric patients with uveitis treated at Emory Eye Center and Children’s Hospital of Atlanta between 2009 and 2020. Fluorescein angiography (FA) images were reviewed and graded according to the Angiography Scoring for Uveitis Working Group system.
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The mean FA score was significantly different in the group of eyes with clinically active vs. inactive uveitis and in the group of eyes with moderate vs. severe visual impairment. Panuveitis had the highest mean FA score, followed by intermediate uveitis, while posterior uveitis and anterior uveitis had the lowest mean scores, according to the poster. Noninfectious uveitis was associated with optic disc hyperfluorescence, retinal vascular staining, capillary leakage and pinpoint leaks, while infectious uveitis was associated with retinal pooling, the authors wrote.
“FA in pediatric uveitis patients revealed specific pathology associated with uveitis location, visual acuity and uveitis etiology beyond that of clinical examination alone and uncovered activity in clinically quiescent disease. Therefore, a standardized quantitative FA scoring system to interpret FA imaging is useful in the management of uveitis in pediatric patients,” the authors wrote in the study abstract.
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Ye S, et al. Characterization of fluorescein angiography features in pediatric patients with uveitis. Presented at: Real World Ophthalmology; Nov. 5, 2022 (virtual meeting).
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