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May 03, 2024
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Researchers find potential link between CKD, migraines in Korean adults

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Key takeaways:

  • Results showed an 11% reduction in the likelihood of migraines during the study.
  • Specific demographic and health conditions influenced outcomes.

There may be a link between chronic kidney disease and the onset of migraines in Korean adults, according to data from a nationwide longitudinal follow-up study.

“CKD often gives rise to various neurological issues, including cerebrovascular disorders such as stroke, cognitive impairment, white matter diseases and headaches,” Mi Jung Kwon, MD, of the Hallym University Sacred Heart Hospital, and colleagues wrote. “While headaches are commonly experienced by individuals with CKD, there is a notable lack of statistical evaluations within population-based studies that specifically investigate the relationship between CKD and incident migraines, raising questions about whether CKD may be one of the risk comorbidities inducing migraines in the Korean population.”

Source: Adobe Stock.
Results showed an 11% reduction in the likelihood of migraines during the study. Image: Adobe Stock.

Researchers used data from the Korean National Health Insurance Service-Health Screening Cohort to study 15,443 patients with CKD and 61,772 matched controls from 2002 to 2019. Patients included were aged 40 years and older.

The study defined CKD as a CKD diagnosis based on the ICD-10 code N18 or diagnosis of unspecified renal failure on two or more separate occasions. Migraine was defined the presence of the ICD-10 code G43 and if patients required a cure for their symptoms.

Researchers found an 11% reduction in the likelihood of patients experiencing migraines during the 16-year study period after accounting for various factors. Subgroup analysis showed specific demographic and health conditions influenced outcomes.

Patients aged 70 or older, women, those who are overweight, nonsmokers and those without hypertension or diabetes had a significant link between CKD and a lower probability of migraine occurrence, according to the researchers.

“Our study suggested a potential slight reduction in the likelihood of migraine development among Korean adults with CKD, particularly in certain subgroups,” they wrote. “These findings emphasize the importance of vigilant follow-up and preventive management for migraine occurrence, especially among male CKD patients under the age of 70 with hypertension.”